The Korean Journal of Blood Transfusion : eISSN 2383-6881 / pISSN 1226-9336

Table. 1.

Table. 1.

Indications for RHD genotyping in Europeans and Koreans

Indication Europeans Koreans
Non-invasive prenatal testing (NIPT) for fetal RhD antigen presence or absence Verification of the fetus’s RhD negativity when a D negative-mother is pregnant with a child from a D positive-biological father Not used
Determination of RhIG administration suitability in prenatal patients through RhD testing Confirmation of Weak D type 1, 2, 3, 4.0 and 4.1 in cases of RhD weak expression Verification of Asian-type DEL presence in D negative-mothers
Confirmation of weak D 1, 2, 3, 4.0, and 4.1 and Asian-type DEL phenotype in patients RHD genotyping is recommended in over 75% of D variants for Weak D type 1, 2, 3, 4.0 and 4.1 With approximately 15% prevalence of the Asian-type DEL in D-negative individuals, RHD genotyping is recommended
Identification of Asian-type DEL in blood samples from donors with a D negative-phenotype Due to the low prevalence of the DEL phenotype, cost-effective molecular screening is needed With approximately 15% prevalence of the Asian-type DEL, RHD genotyping is recommended
Determination of RhD antigen in patients with discrepant or weak RhD antigen tests RHD genotyping is recommended in cases of RhD antigen test discrepancies and weak expressions RHD genotyping is recommended in cases of RhD antigen test discrepancies and weak expressions
Korean J Blood Transfus 2024;35:27-32 https://doi.org/10.17945/kjbt.2024.35.1.27
© 2024 Korean J Blood Transfus