The Korean Journal of Blood Transfusion : eISSN 2383-6881 / pISSN 1226-9336

Table. 3.

Table. 3.

Representative cases of an ABO discrepancy resolved by ABO genotyping

Case No. Cell typing Serum typing Phenotype Genotype Interpretation Identified cause of ABO discrepancy
Anti-A Anti-B Anti-A1 A-cell B-cell Auto
1 ± ± 4+ 4+ AwBw O.01.02/O.01.02 Extra red cell reactivity Auto-agglutinin
2 + 4+ + 2+ - AwBw B.01/B.01 Paraproteinemia due to MM
3 3+ 4+ Aw AW.36/O.01.01 Weak red cell reactivity ABO subgroup
4 2+ 3+ Aw A1.02/A1.02 Hematologic malignancy (AML)
5 NT 4+ NT O* BW.variant/O.01.06 ABO subgroup & hematologic malignancy (MDS)
6 4+ 4+ 2+ A2B cisAB.01/O.01.01 Extra serum reactivity ABO subgroup
7 4+ 4+ 3+ A1 A1.02/A1.02 Unexpected antibody (anti-M)
8 2+ O O.01.01/O.01.01 Weak serum reactivity Age-related (6 months old)
9 4+ O O.01.01/O.01.01 BMT (A+→O+)

*Adsorption elution test was positive on B antigen.

BW.variant allele refers to the B.01 allele with g.10925C>T, according to the reference sequence NG_006669.2.

Recipient blood type was A+ and donor blood type was O+.

Abbreviations: AML, acute myeloid leukemia; BMT, bone marrow transplantation; MDS, myelodysplastic syndrome; MM, multiple myeloma; NT, not tested.

Korean J Blood Transfus 2023;34:12-20 https://doi.org/10.17945/kjbt.2023.34.1.12
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