The Korean Journal of Blood Transfusion

Table. 3. Table 3

Representative cases of an ABO discrepancy resolved by ABO genotyping

Case No.	Cell typing			Serum typing			Phenotype	Genotype	Interpretation	Identified cause of ABO discrepancy
Case No.	Anti-A	Anti-B	Anti-A1	A-cell	B-cell	Auto	Phenotype	Genotype	Interpretation	Identified cause of ABO discrepancy
1	±	±	–	4＋	4＋	＋	AwBw	O.01.02/O.01.02	Extra red cell reactivity	Auto-agglutinin
2	+	4+	+	2+	-	＋	AwBw	B.01/B.01	Extra red cell reactivity	Paraproteinemia due to MM
3	3＋	–	–	–	4＋	–	Aw	AW.36/O.01.01	Weak red cell reactivity	ABO subgroup
4	2＋	–	–	–	3＋	–	Aw	A1.02/A1.02		Hematologic malignancy (AML)
5	–	–	NT	4＋	–	NT	O*	BW.variant^†/O.01.06		ABO subgroup & hematologic malignancy (MDS)
6	4＋	4＋	–	–	2＋	–	A2B	cisAB.01/O.01.01	Extra serum reactivity	ABO subgroup
7	4＋	–	4＋	＋	3＋	–	A1	A1.02/A1.02	Extra serum reactivity	Unexpected antibody (anti-M)
8	–	–	–	2＋	–	–	O	O.01.01/O.01.01	Weak serum reactivity	Age-related (6 months old)
9	–	–	–	–	4＋	–	O	O.01.01/O.01.01	Weak serum reactivity	BMT (A＋→O＋)^‡

*Adsorption elution test was positive on B antigen.

^†BW.variant allele refers to the B.01 allele with g.10925C>T, according to the reference sequence NG_006669.2.

^‡Recipient blood type was A＋ and donor blood type was O＋.

Abbreviations: AML, acute myeloid leukemia; BMT, bone marrow transplantation; MDS, myelodysplastic syndrome; MM, multiple myeloma; NT, not tested.