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Type Distribution of Unexpected Red Cell Antibodies in Patients with Malignancy
악성종양 환자에서 동정된 적혈구 비예기항체의 형별 분포
The Korean Society of Blood Transfusion 2012;23:58−67
Published online April 30, 2012
© 2012 The Korean Society of Blood Transfusion.

Chang Eun Yoon1, Jin Kyung Lee1,2, Young Jun Hong1,2, Seok-Il Hong1,2, Bo You Yun1, Heui Seung Jo3, Yoon Hwan Chang1,2
Background:Performance of antibody screening and identification tests before blood transfusion is important because the unexpected presence of red cell antibodies may cause hemolytic transfusion reactions. Many patients with malignancy undergo transfusion in order to overcome pancytopenia due to disease itself or chemotherapy. We investigated the type distribution of unexpected red cell antibodies in cancer patients and compared our results with those of other institutions.
Methods:From January 2008 to June 2011, 30,989 serum samples were screened using a LISS/Coombs card and ID-DiaCell I, II (DiaMed AG, Morat, Switzerland). Data-Cyte Plus Reagent Red Blood Cells (Medion Diagnostics, Düdingen, Switzerland) were used in performance of antibody identification tests.
Results:Out of 30,989 serum samples, 180 cases (0.58%) showed screening-positive results, and unexpected antibodies were identified in 72 cases. The type of unexpected antibody observed most often in cancer patients was a member of the Rh antibody group, anti-E in 17 cases (29.8%), followed by anti-Lea in five cases (8.8%) and anti-e in three cases (5.3%). While Rh group antibodies were observed in the colon cancer group, non-Rh group antibodies were observed in the rectal cancer group. And, in the genitourinary cancer group, Lewis group antibodies were more frequently detected than others.
Conclusion:Findings from our study demonstrated a type distribution of unexpected red cell antibodies that was similar to those reported in previous studies. Compared with non-cancerous patients, no difference in type distribution of unexpected red cell antibodies was observed in cancer patients. Some antibodies were frequently observed in certain cancer groups. Further comprehensive research on unexpected antibodies based on location or histologic type of cancer is needed. (Korean J Blood Transfus 2012;23: 0-67)
Keywords : Unexpected antibodies, Cancer, Antibody screening and identification test

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