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Analysis of Reentry Test for the Donors Showing Reactivity or Grey Zone in a HBV Surface Antigen Assay by a Chemiluminescent Immunoassay
화학발광면역법에 의한 HBV 항원선별검사에서 양성 및 Grey Zone 결과를 보인 헌혈자의 헌혈 보류 해제 검사 결과 분석
Korean J Blood Transfus 2018;29:301−309
Published online December 31, 2018;
© 2018 The Korean Society of Blood Transfusion.

Sunmi Shin, Jungwon Kang, Kyeong Rak Lee, Geon Sik Shin, Jae-won Kang, Young Ik Seo, Hyukki Min

Blood Transfusion Research Institute, Korean Red Cross, Wonju, Korea
대한적십자사 혈액수혈연구원
Jae-won Kang
Blood Transfusion Research Institute, Korean Red Cross, 50 Hyeoksin-ro, Wonju 26465, Korea
Tel: 82-33-811-0231, Fax: 82-33-811-0240, E-mail:, ORCID:
Received July 11, 2018; Revised August 2, 2018; Accepted September 15, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: If donors who were deferred due to the reactivity or grey zone in HBV surface antigen (HBsAg) assay want to donate blood again, they need to pass reentry tests. On the other hand, approximately half of the donors who are subject to the reentry tests cannot be reentered. This study examined the association between the sample to cutoff (S/Co) value of the HBsAg assay and the final results of the reentry test.
Methods: This study analyzed the S/Co values of the HBsAg assay and the final results of the reentry tests for the 3,947 donors from January 2008 to December 2017 using the database of Blood Information Management System of the Korean Red Cross.
Results: 1,767 donors (44.8%) were not reentered among 3,947 deferred donors. Among 1,585 donors showing ≥10 of the S/Co value in the HBsAg screening test, 1,542 donors (97.3%) were not reentered. The additional reentry tests were performed on 120 donors who were not reentered in the first reentry test; 98 donors (81.7%) were still not reentered. Overall, 4.6% of the donors showing a grey zone in the HBsAg assay were not reentered.
Conclusion: The reentry test needs to be restricted for the deferred donors showing a more than 10 S/Co value. The application of the grey zone of current HBsAg assay will need to be continued to enhance the HBV-related blood safety.
Keywords : HBsAg, S/Co, Reentry


December 2018, 29 (3)
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