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Difference in Characteristics in the Formation of Anti-E and Anti-E/-c in Patients with the CDe Phenotype
CDe 표현형의 환자에서 항-E와 항-E/-c 항체 생성 특이성의 차이
Korean J Blood Transfus 2018;29:282−290
Published online December 31, 2018;
© 2018 The Korean Society of Blood Transfusion.

Gyu-Dae An, Kyeong-Hee Kim, Hyeon-Ho Lim, In-Hwa Jeong

Department of Laboratory Medicine, Dong-A University College of Medicine, Busan, Korea
동아대학교 의과대학 진단검사의학교실
Kyeong-Hee Kim
Department of Laboratory Medicine, Dong-A University College of Medicine, 32 Daeshingongwon-ro, Seo-gu, Busan 49201, Korea
Tel: 82-51-240-2850, Fax: 82-51-255-9366, E-mail:, ORCID:
Received July 6, 2018; Revised August 6, 2018; Accepted September 10, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Anti-E or paired anti-E/-c antibodies can develop in patients with the Rh CDe phenotype. This study examined the differences in transfusion in patients with the CDe phenotype according to formation of anti-E or anti-E/-c antibodies.
Methods: Retrospective reviews were carried out on the results of antibody identification tests performed in 2014. The Rh phenotype and antibody specificity were investigated. The transfusion and medical records of patients with the CDe phenotype were examined.
Results: In total, 76 patients were included in the review. Of these 76 patients, 38 (50.0%) were of the CDe phenotype. Anti-E antibodies were the most frequent (60.5%), followed by anti-E/-c antibodies (23.7%). The total transfusion units and platelet transfusion units were significantly higher in patients with anti-E/-c antibodies (P=0.028 and P=0.01, respectively). The distribution of categorized diseases was similar in the patients with the anti-E and anti-E/-c antibodies. A frequency of transfusion episodes greater than or equal to four was higher in patients with hepatobiliary diseases (85.7%).
Conclusion: In CDe phenotype patients, platelet transfusion was significantly higher in the anti-E/-c positive group than the anti-E positive group, indicating that platelets play a role in red blood cell alloimmunization. Because E is the most immunogenic antigen in Korea, it is important to define the disease group, in which patients with CDe phenotype require a transfusion of E and c-negative blood.
Keywords : Transfusion, Alloimmunization, Rh phenotype, Platelet


December 2018, 29 (3)
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