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Analysis of Application of Massive Transfusion Protocol for Trauma Patients at a Single Tertiary Referral Hospital
단일 3차 의료기관에서 외상환자에 대한 대량수혈 프로토콜 적용 분석
Korean J Blood Transfus 2018;29:262−272
Published online December 31, 2018;
© 2018 The Korean Society of Blood Transfusion.

Hyerin Kim1, Dong-Won Yoo2, Hyerim Kim1, Kyung-Hwa Shin1, Hyun-Ji Lee2, Chulhun L. Chang2, Hyung-Hoi Kim1

Department of Laboratory Medicine, Pusan National University Hospital1, Busan, Department of Laboratory Medicine, Pusan National University Yangsan Hospital2, Yangsan, Korea
부산대학교병원 진단검사의학과1, 양산부산대학교병원 진단검사의학과2
Hyung-Hoi Kim
Department of Laboratory Medicine, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea
Tel: 82-51-240-7418, Fax: 82-51-240-6560, E-mail:, ORCID:
Received October 15, 2018; Revised November 6, 2018; Accepted November 21, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Massive hemorrhage due to trauma is one of the major causes of death in trauma patients, and the quick supply of appropriate blood products is critical in order to reduce the mortality rate. We introduced a massive transfusion protocol (MTP) for safe and rapid transfusion of trauma patients. Using records collected since its adoption, we compared the characteristics of MTP applied group (MTP group) and MTP not applied group (non-MTP group) to determine whether there is an indicator for predicting patients to be treated with MTP.
Methods: We retrospectively reviewed the electronic medical records and laboratory findings of patients who received massive transfusions in the trauma emergency room of a single tertiary hospital from February to August 2018. We analyzed various laboratory test results, the amount and ratio of the transfused blood products, and the time required for blood products to be released for the MTP group and the non-MTP group.
Results: Of the 54 trauma patients who received massive transfusions, 31 were in the MTP group and 22 in the non-MTP group. There was no significant difference in initial vital signs (except blood pressure) and laboratory test results. Also there was no difference in the amount and ratio of blood products, but the time required for blood product release was shorter in the MTP group.
Conclusion: There was no significant difference in clinical findings such as initial vital signs and laboratory test results between the MTP and non-MTP groups, but required blood products were prepared and released more quickly for the MTP group.
Keywords : Massive hemorrhage, Massive transfusion, Trauma


December 2018, 29 (3)
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