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Effect of Blood Donation on the Donor’s Hemorheological Properties
헌혈이 헌혈자의 혈유변학적 지표에 미치는 영향
Korean J Blood Transfus 2018;29:229−239
Published online December 31, 2018;
© 2018 The Korean Society of Blood Transfusion.

Byoung Kwon Lee

Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea
연세대학교 의과대학 내과학교실 심장내과
Byoung Kwon Lee
Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 06273, Korea
Tel: 82-2-2019-3307, Fax: 82-2-3463-3882, E-mail:, ORCID:
Received October 22, 2018; Revised November 6, 2018; Accepted November 7, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.
Keywords : Blood viscosity, Erythrocyte aggregation, Hematocrit, ferritin, Blood donors


December 2018, 29 (3)
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