Identification of Rh alloimmunization after Rh antigen mismatched red cell transfusion based on the transfusion time and Rh phenotype of donor and recipient
| PatientNo. | Sex/age | Alloantibody | Unexpected antibody screening | Transfusion date | Transfusion-alloantibody positive (days) | Transfused Rh mismatched/ total RBCs (unit) | Diagnosis | Rh phenotype (transfused RBC) | Rh phenotype (patient) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive | Negative | C | c | E | e | ||||||||
| 1 | M/65 | Anti-E | 2017-01-24 | 2016-08-27 | 2016-08-27 | 150 | 1/1 | Malignant neoplasm of colon | ＋ | ＋ | ＋ | ＋ | CDe |
| 2 | F/73 | Anti-E＋ UnID | 2017-04-19 | 2017-03-10 | 2017-03-11 | 39 | 1/1 | Subarachnoid hemorrhage | – | ＋ | ＋ | – | CDe |
| 3 | F/60 | Anti-E＋ UnID | 2017-05-01 | 2016-09-19 | 2016-09-21 | 222 | 1/1 | Chronic kidney disease | ＋ | ＋ | ＋ | ＋ | CDe |
| 4 | M/66 | Anti-E＋ UnID | 2017-05-13 | 2016-07-14 | 2016-07-14 | 303 | 1/3 | B-cell lymphoma | ＋ | ＋ | ＋ | ＋ | CDe |
| 5 | M/59 | Anti-E | 2017-09-13 | 2017-07-17 | 2017-07-18 | 57 | 1/1 | Intrahepatic bile duct carcinoma | ＋ | ＋ | ＋ | ＋ | CDe |
| 6 | F/81 | Anti-E | 2017-09-18 | 2017-08-30 | 2017-08-30 | 19 | 1 |
Heart failure | – | ＋ | ＋ | – | NT |
| 7 | F/78 | Anti-E＋ Auto-Ab | 2017-10-13 | 2017-10-01 | 2017-10-01 | 12 | 1 |
Intrahepatic bile duct carcinoma | ＋ | ＋ | ＋ | ＋ | NT |
| 8 | F/86 | Anti-E＋ Auto-Ab | 2017-11-10 | 2017-10-13 | 2017-10-13 | 28 | 1/1 | Infection and inflammatory reaction due to internal joint prosthesis | ＋ | ＋ | ＋ | ＋ | CcDe |
| 9 | M/45 | Anti-E＋ Auto-Ab | 2017-11-16 | 2017-11-06 | 2017-11-06 | 10 | 1/1 | Acute myocardial infarction | ＋ | ＋ | ＋ | ＋ | CDe |
| 10 | M/50 | Anti-E＋ Anti-c | 2017-12-05 | 2017-11-05 | 2017-11-07 | 28 | 1/4 | Non-rheumatic mitral (valve) insufficiency | ＋ | ＋ | ＋ | ＋ | CDe |
| 11 | M/74 | Anti-E＋ Anti-c＋ Auto-Ab | 2017-12-21 | 2017-06-13 | 2017-06-13 | 191 | 1/3 | Chronic kidney disease | ＋ | ＋ | ＋ | ＋ | CDe |
*Assumed to be mismatched based on donor’s phenotype, but not confirmed by recipient’s phenotype.
Abbreviations: UnID-Ab, unidentified antibody; Auto-Ab, autoantibody; NT, not tested.