The Korean Journal of Blood Transfusion : eISSN 2383-6881 / pISSN 1226-9336

Table. 2.

Table. 2.

Advantages and disadvantages of the buffy-coat method over the platelet-rich plasma method for whole blood processing

Advantages Disadvantages
∙Low contamination of both the red blood cells and platelet concentrate with white blood cells [6] ∙Loss of RBCs, especially neocyte (range from 18 to 28 mL) [7]
∙Improved yields of platelets and plasma [6] ∙Small loss of some coagulation proteins activity in buffy-coat plasma [8,9]
∙Reduced platelets activation [10,11]
∙Higher proportion of discoid platelets and better hypotonic shock response (HSR) at the end of storage [12] ∙Complex and relatively high-cost procedure
∙Less incidence of febrile nonhemolytic transfusion reactions (FNHTRs) after transfusion of a platelet concentrate [13]
∙Availability of whole blood-derived prestorage-pooled platelets
∙Logistic advantages because buffy-coat can be processed the same day or the following day [14]
∙Improved work flow
∙Greater flexibility in the use of platelet additive solution (PAS) and pathogen reduction technology (PRT) [15,16]
Korean J Blood Transfus 2020;31:201-10 https://doi.org/10.17945/kjbt.2020.31.3.201
© 2020 Korean J Blood Transfus