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Table. 4.

Table. 4.

Brief history of a sixth patient of which anti-HLA and anti-HNA antibodies were investigated in donor blood components

TimeMain eventClinical findingRadiologic findingsRetrospective anti-HLA and anti-HNA Ab screening

 Anti-HLA Anti-HNA
HD #20 07:50Non-specificNon-specificSmall amount of bilateral pleural effusion
HD #21 12:20~13:101 unit of SDP (#1) transfusedNo significant transfusion reactionNegativeHNA1a Ab positive (gray zone: MFI 721.4)
HD #21 13:10~13:501 unit of SDP (#2) transfusedNo significant transfusion reactionNegativeNegative
HD #21 15:55Patient complained dyspneaSpO2 85%, BP 149/84, PR 112, RR 22
HD #21 17:08~ HD #22 10:08Patient continuously complained dyspneaSpO2 88~100%, supportive care with oxygen supply (nasal cannula or rebreathing mask)Newly developed GGO and consolidation in both lungs, small amount of bilateral pleural effusion
HD #22 11:43~12:041 unit of SDP (#3) transfusedNo significant transfusion reactionNegativeNegative
HD #22 12:04~12:261 unit of SDP (#4) transfusedSpO2 87% on 9 L/min, rebreathing maskHLA class I Ab positive (gray zone)Negative
HD #22 15:28Intubation was doneSupportive care for respiratory failureMildly aggravation of GGO and consolidation in both lungs

Abbreviations: HD, hospital day; SDP, single donor platelet; BP, blood pressure; PR, pulse rate; RR, respiratory rate; GGO, ground-glass opacity; HLA, human leukocyte antigen; HNA, human neutrophil antigen; Ab, antibody; MFI, mean fluorescence intensity.

Korean J Blood Transfus 2019;30:219-29 https://doi.org/10.17945/kjbt.2019.30.3.219
© 2019 Korean J Blood Transfus