The Korean Journal of Blood Transfusion : eISSN 2383-6881 / pISSN 1226-9336

Table. 1.

Table. 1.

Comparison of TRALI definitions between the 2004 CCC definition and the 2019 new consensus [18]

2004 CCC TRALI definition2019 TRALI new consensus
1. TRALI1. TRALI Type I
 a. ALI   i. acute onset   ii. hypoxemia (PaO2/FiO2≤300, or SpO2<90% on room air, or other clinical evidence of hypoxemia)   iii. bilateral infiltrate on frontal chest radiograph   iv. no evidence of left atrial hypertension (i.e., circulatory overload)  b. no preexisting ALI before transfusion  c. during or within 6 hr of transfusion  d. no temporal relationship to an alternative risk factor for ALI: patients who have no risk factors for ARDS and meet the following criteria  a. i. acute onset   ii. hypoxemia (PaO2/FiO2≤300 or SpO2<90% on room air)   iii. clear evidence of bilateral pulmonary edema on imaging (e.g., chest radiograph, chest CT, or ultrasound)   iv. no evidence of LAH or, if LAH is present, is judged to not be the main contributor to the hypoxemia  b. onset during or within 6 hr of transfusion  c. no temporal relationship to an alternative risk factor for ARDS
2. Possible TRALI2. TRALI Type II
 a. ALI  b. no preexisting ALI before transfusion  c. during or within 6 hr of transfusion  d. a clear temporal relationship to an alternative risk factor for ALI: patients who have risk factors for ARDS (but who have not been diagnosed with ARDS) or who have existing mild ARDS (PaO2/FiO2 of 200~300), but whose respiratory status deteriorates and is judged to be due to transfusion based on:  a. findings as described in categories a and b of TRALI type I, and  b. stable respiratory status in the 12 hr before transfusion

Abbreviations: CCC, Canadian Consensus Conference; TRALI, transfusion-related acute lung injury; ALI, acute lung injury; ARDS, acute respiratory distress syndrome; LAH, left atrial hypertension.

Korean J Blood Transfus 2019;30:219-29 https://doi.org/10.17945/kjbt.2019.30.3.219
© 2019 Korean J Blood Transfus