The Korean Journal of Blood Transfusion : eISSN 2383-6881 / pISSN 1226-9336

Table. 1.

Table. 1.

Mechanisms of various medication and procedures used for desensitization

 CategoryMedication or procedureTargetMechanism of action
Antibody removalPlasmapheresisHLA antibodyAntibody removal, exchange plasma into replacement fluid
ImmunoadsorptionHLA antibodyStaphylococcal protein A or protein G, IgG antibody removal
IdeSHLA antibodyIgG-degrading enzyme of Streptococcus pyogenes, cleavage of IgG to F(ab’)2 and Fc portion
Intravenous immunoglobulinVariousUnclear, F(ab’)2 and Fc dependent pathway etc.
Blocking antibody formationRituximabPre, mature, memory B cellsAnti-CD20
BortezomibPlasma cellProteasome inhibitor
TocilizumabB cell, Plasma cellIL-6 receptor antagonist
Inactivation of complement systemC1-INHComplement systemC1 esterase inhibitor
Inactivation of complement systemEculizumabComplement systemC5 convertase inhibitor
Korean J Blood Transfus 2019;30:1-14 https://doi.org/10.17945/kjbt.2019.30.1.1
© 2019 Korean J Blood Transfus